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However, a DPPIV inhibitor retained its glucose lowering effects in these mice, suggesting that the GLP-1R on the beta cell is not necessary for these effects, and that perhaps extra-islet receptors are responsible for the incretin effects of GLP-1

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Evidence that lithium alters phosphoinositide metabolism: chronic administration elevates primarily D- myo -inositol-1-phosphate in cerebral cortex of the rat J Neurochem 1981